Effectiveness of Modified Vaccinia Ankara-Bavaria Nordic Vaccination in a Population at High Risk of Mpox: A Spanish Cohort Study.

BACKGROUND: With more than 7500 cases reported since April 2022, Spain has experienced the highest incidence of mpox in Europe. From 12 July onward, the modified vaccinia Ankara-Bavaria Nordic (MVA-BN) smallpox vaccine was offered as pre-exposure prophylaxis for those receiving pre-exposure prophylaxis for human immunodeficiency virus (HIV-PrEP). Our aim was to assess the effectiveness of 1 dose of MVA-BN vaccine as pre-exposure prophylaxis against mpox virus (MPXV) infection in persons on HIV-PrEP. METHODS: National retrospective cohort study between 12 July and 12 December 2022. Individuals aged ≥18 years receiving HIV-PrEP as of 12 July with no previous MPXV infection or vaccination were eligible. Each day, we matched individuals receiving a first dose of vaccine and unvaccinated controls of the same age and region. We used a Kaplan-Meier estimator, calculated risk ratios (RR) and vaccine effectiveness (VE = [1 - RR]x100). RESULTS: We included 5660 matched pairs, with a median follow-up of 62 days (interquartile range, 24-97). Mpox cumulative incidence was 5.6 per 1000 (25 cases) in unvaccinated and 3.5 per 1000 (18 cases) in vaccinated. No effect was found during days 0-6 post-vaccination (VE, -38.3; 95% confidence interval [CI], -332.7 to 46.4), but VE was 65% at ≥7 days (95% CI, 22.9 to 88.0) and 79% at ≥14 days (95% CI, 33.3 to 100.0) post-vaccination. CONCLUSIONS: One dose of MVA-BN vaccine offered protection against mpox in most-at-risk population shortly after the vaccination. Further studies need to assess the VE of a second dose and the duration of protection over time.

[Epidemiology of Campylobacteriosis in Castile and Leon, Spain,during the period 2008-2015]. / Epidemiología de la campilobacteriosis en Castilla y León durante el período 2008-2015.

OBJECTIVE: Campylobacter is considered the most frequent agent of gastroenteritis in humans all around the world. The aim of this study was to know the incidence, trend and seasonality of notified campylobacteriosis cases in Castile and Leon, Spain, from 2008 to 2015. In addition, to describe the type of case and source of notification, and study the influence of age, sex and Campylobacter species on the hospitalization of cases. METHODS: Retrospective cross-sectional study with a time series analysis. Data on notified campylobacteriosis cases were collected from the Epidemiological Surveillance System of Castile and Leon (2008-2015). Incidence rates and incidence rate ratios by age, sex and year of notification were calculated. In order to estimate trend and seasonality, a time series analysis was performed using a multiplicative method and adjusted to a linear and exponential model. RESULTS: From 4,330 cases analyzed, 49.4% of children aged under 5 were affected. The ratio of men to women was 1.43 and 61.8% of cases were notified from secondary care. C. jejuni was isolated from 72.3% of samples (n=2,593). Incidence rate ranged from 11.42 cases per 100,000 inhabitants in 2008 to 33.53 in 2015. The seasonality range was from 71.97% (13th four-week period) to 125.54% (9th four-week period). Hospitalization reached 62.5% for people aged 60 or over. CONCLUSIONS: A growing trend of notified campylobacteriosis cases is observed in Castile and Leon (2008-2015), mainly in children aged under 5, with a peak in summer months. Males are more affected than females and hospitalization increases with age.

OBJETIVO: El Campylobacter es considerado el agente causal más común en el mundo de gastroenteritis humana. El objetivo de este estudio fue conocer la incidencia, tendencia y estacionalidad de los casos de campilobacteriosis declarados en Castilla y León (periodo 2008-2015) así como describir el tipo de presentación y nivel asistencial de declaración y estudiar la influencia de la edad, sexo y especie de Campylobacter en la hospitalización de las personas afectadas. METODOS: Estudio retrospectivo con análisis de la serie temporal. Los datos se obtuvieron de los casos notificados al Sistema de Vigilancia Epidemiológica de Castilla y León (2008-2015). Para cada año, se hallaron tasas de incidencia y razón de tasas de incidencia globales y por edad y sexo. Se analizó la tendencia y estacionalidad de la serie temporal mediante método multiplicativo, ajustándose a un modelo lineal y exponencial. RESULTADOS: Se analizaron 4.330 casos, con un 49,4% de afectación en menores de 5 años. La ratio hombre/mujer fue 1,43 y un 61,8% de casos se notificó desde atención especializada. C. jejuni se aisló en un 72,3% de muestras (n=2.593). La tasa de incidencia pasó de 11,42 casos por 100.000 habitantes en 2008 a 33,53 en 2015. El índice de estacionalidad varió entre 71,97% (cuatrisemana 13) y 125,54% (cuatrisemana 9). La hospitalización en ≥60 años alcanzó el 62,5%.

Epidemiología de la campilobacteriosis en Castilla y León durante el período 2008-2015 / Epidemiology of campylobacteriosis in Castile and Leon, Spain, during the period 2008-2015

Fundamentos: El Campylobacter es considerado el agente causal más común en el mundo de gastroenteritis humana. El objetivo de este estudio fue conocer la incidencia, tendencia y estacionalidad de los casos de campilobacteriosis declarados en Castilla y León (periodo 2008-2015) así como describir el tipo de presentación y nivel asistencial de declaración y estudiar la influencia de la edad, sexo y especie de Campylobacter en la hospitalización de las personas afectadas. Métodos: Estudio retrospectivo con análisis de la serie temporal. Los datos se obtuvieron de los casos notificados al Sistema de Vigilancia Epidemiológica de Castilla y León (2008-2015). Para cada año, se hallaron tasas de incidencia y razón de tasas de incidencia globales y por edad y sexo. Se analizó la tendencia y estacionalidad de la serie temporal mediante método multiplicativo, ajustándose a un modelo lineal y exponencial. Resultados: Se analizaron 4.330 casos, con un 49,4% de afectación en <5 años. La ratio hombre/mujer fue 1,43 y un 61,8% de casos se notificó desde atención especializada. C. jejuni se aisló en un 72,3% de muestras (n=2.593). La tasa de incidencia pasó de 11,42 casos por 100.000 habitantes en 2008 a 33,53 en 2015. El índice de estacionalidad varió entre 71,97% (cuatrisemana 13) y 125,54% (cuatrisemana 9). La hospitalización en ≥60 años alcanzó el 62,5%. Conclusiones: Se observa una tendencia ascendente de los casos notificados de campilobacteriosis en Castilla y León (2008-2015), especialmente en <5 años, con una clara estacionalidad en verano. Predomina en hombres, y la hospitalización aumenta con la edad (AU)

Background: Campylobacter is considered the most frequent agent of gastroenteritis in humans all around the world. The aim of this study was to know the incidence, trend and seasonality of notified campylobacteriosis cases in Castile and Leon, Spain, from 2008 to 2015. In addition, to describe the type of case and source of notification, and study the influence of age, sex and Campylobacter species on the hospitalization of cases. Methods: Retrospective cross-sectional study with a time series analysis. Data on notified campylobacteriosis cases were collected from the Epidemiological Surveillance System of Castile and Leon (2008-2015). Incidence rates and incidence rate ratios by age, sex and year of notification were calculated. In order to estimate trend and seasonality, a time series analysis was performed using a multiplicative method and adjusted to a linear and exponential model. Results: From 4,330 cases analyzed, 49.4% of children aged under 5 were affected. The ratio of men to women was 1.43 and 61.8% of cases were notified from secondary care. C. jejuni was isolated from 72.3% of samples (n=2,593). Incidence rate ranged from 11.42 cases per 100,000 inhabitants in 2008 to 33.53 in 2015. The seasonality range was from 71.97% (13th fourweek period) to 125.54% (9th four-week period). Hospitalization reached 62.5% for people aged 60 or over. Conclusions: A growing trend of notified campylobacteriosis cases is observed in Castile and Leon (2008-2015), mainly in children aged under 5, with a peak in summer months. Males are more affected than females and hospitalization increases with age (AU)

Menú escolar de los centros de enseñanza secundaria de Madrid: conocimiento y cumplimiento de las recomendaciones del Sistema Nacional de Salud / Secondary school menu in Madrid (Spain): knowledge and adherence to the Spanish National Health System recommendations

Objetivo: Establecer, en la Comunidad de Madrid, el grado de conocimiento y cumplimiento de las recomendaciones del Documento de consenso del Sistema Nacional de Salud sobre la alimentación en los centros educativos. Métodos: Estudio transversal con una muestra aleatoria de 182 centros de enseñanza secundaria de Madrid con comedor escolar en el curso 2013-2014. A través de Internet y entrevista telefónica se recogió información sobre las características de los centros y el conocimiento de las recomendaciones, y se recabó una copia del menú escolar. Para cada ítem alimentario se calculó la media de raciones consumidas y el porcentaje de centros dentro del rango recomendado. La adherencia global se calculó como la media del número de alimentos (0-12) dentro del rango. Resultados: El 65,5% de los centros desconocían el documento de consenso. La oferta de arroz, pasta, pescados, huevos, ensalada y fruta fue inferior a la recomendada, y la de carne, guarniciones y otros postres fue superior. El porcentaje de colegios dentro del rango para cada ítem alimentario varió entre el 13% y el 95%. La media de adherencia global fue de 6,3, sin diferencias en función de si el centro disponía o no de cocina propia o de un responsable de nutrición. Conclusión: El grado de adherencia a las recomendaciones fue variable. Se aconseja aumentar la oferta de cereales, huevos, pescado, ensalada y fruta. Se requieren programas de difusión e implementación de las recomendaciones del documento de consenso, contando con profesionales adecuadamente formados, para mejorar el valor nutricional del menú escolar (AU)

Objective: To establish the degree of knowledge and adherence to the Spanish National Health System recommendations on nutrition in schools in the Autonomous Community of Madrid. Methods: Cross-sectional study of a random sample of 182 secondary schools from Madrid, during 2013-2014 school year. Information on the characteristics of the schools and the knowledge of the recommendations was collected by internet and telephone interviews, as well as a copy of the school menu. The average number of rations per week offered for each food item and the percentage of schools within the recommended range were calculated. The overall adherence was obtained as the mean of food items (0-12) within the range. Results: 65.5% of the schools were unaware of the national recommendations. The supply of rice, pasta, fish, eggs, salad and fruit was lower than recommended, whereas for meat, accompaniment and other desserts was higher. The percentage of schools within the range for each food item varied between 13% and 95%. The mean of overall adherence was 6.3, with no differences depending on whether the menu was prepared or not at schools or there was or not a person in charge of nutrition standards. Conclusions: The degree of adherence to the recommendations was variable, being advised to increase the supply of cereals, eggs, fish, salad and fruit. Programs for dissemination and implementation of the recommendations, leaded by trained professionals, are required to improve the nutritional value of school menu (AU)

[Secondary school menu in Madrid (Spain): knowledge and adherence to the Spanish National Health System recommendations]. / Menú escolar de los centros de enseñanza secundaria de Madrid: conocimiento y cumplimiento de las recomendaciones del Sistema Nacional de Salud.

OBJECTIVE: To establish the degree of knowledge and adherence to the Spanish National Health System recommendations on nutrition in schools in the Autonomous Community of Madrid. METHODS: Cross-sectional study of a random sample of 182 secondary schools from Madrid, during 2013-2014 school year. Information on the characteristics of the schools and the knowledge of the recommendations was collected by internet and telephone interviews, as well as a copy of the school menu. The average number of rations per week offered for each food item and the percentage of schools within the recommended range were calculated. The overall adherence was obtained as the mean of food items (0-12) within the range. RESULTS: 65.5% of the schools were unaware of the national recommendations. The supply of rice, pasta, fish, eggs, salad and fruit was lower than recommended, whereas for meat, accompaniment and other desserts was higher. The percentage of schools within the range for each food item varied between 13% and 95%. The mean of overall adherence was 6.3, with no differences depending on whether the menu was prepared or not at schools or there was or not a person in charge of nutrition standards. CONCLUSIONS: The degree of adherence to the recommendations was variable, being advised to increase the supply of cereals, eggs, fish, salad and fruit. Programs for dissemination and implementation of the recommendations, leaded by trained professionals, are required to improve the nutritional value of school menu.